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Posts with tag lab

Sunday Seven: Seven tips for trusting lab results

What if the lab results thought to be our own really were not? Hey, mistakes happen in all walks of life. And labs are not immune. But there are a few steps we can take to protect ourselves. Here they are:
  • Ask your doctor about the lab he or she uses. It should be accredited and approved by the College of American Pathologists, a sign the lab meets high standards.

  • If you can see the test tube or slide, make sure your name is on it. If you are in the hospital, make sure your wristband is accurate.

Continue reading Sunday Seven: Seven tips for trusting lab results

Try cutting your health care bills

Health care is expensive, even for those with insurance. My treatment with the breast cancer drug Herceptin cost $5,000 every three weeks for 52 weeks. Insurance paid 80 percent; I was responsible for 20. That's $1,000 every three weeks. Not exactly affordable.

What many of us don't know is that we can play an active role in cutting our health care bills. We can shop around for everything, for example. Before filling a prescription, consider comparing prices offered at mail-order and online pharmacies with those of larger retailers. You may even find that mom and pop shops offer competitive rates since they can set their own pricing. Don't forget about generic drugs too. Ask your doctor if a generic version of your medication is just as good as a brand name drug. If so, go for the price break.

Did you know that lab work is more expensive if you get it at a hospital? Ask your doctor for other trustworthy locations and save a few bucks.

Continue reading Try cutting your health care bills

Screen yourself for cancer .... online

In this age of technology we live in, it seems like all we need to survive is an Internet connection. We can use the web to buy clothes, buy groceries, order dinner, work, do our banking, pay our bills ... the list goes on. The only things we need to leave the house for are visits to the doctor, dentist, hair dresser and so on. Wait, cross going to doctor off the list. You can do that online now too.

What I'm referring to here is Health Check USA, which allows you to screen yourself for a number of things, including cancer, over the Internet. Once you've ordered a test, you'll receive a package in the mail with instructions on how to collect the necessary samples. Once that's done, you send it back and will receive your results over the phone. Sounds simple, huh? Maybe, but I still think visiting your doctor is of the utmost importance.

What do you think? Will you be ordering a test any time soon?

Thought for the Day: An apple peel a day might keep cancer at bay

Remember that old saying -- An apple a day keeps the doctor away? Well, it seems that an apple peel a day might keep cancer at bay, according to a new study.

A dozen compounds have been found called triterpenoids. These compounds found in the peel of an apple either inhibit or kill cancer cells in lab cultures.

"We found that several compounds have potent anti-proliferative activities against human liver, colon and breast cancer cells and may be partially responsible for the anti-cancer activities of whole apples," says Rui Hai Liu, Cornell associate professor of food science.

Previous studies have shown that apples not only fight cancer cells in the laboratory but they also have shown to reduce the number and size of mammary tumors in rats.

So, don't peel those apples. Eat the whole thing!


Marijuana halts lung cancer growth by half

More and more media reports are mentioning the potential merits of marijuana. The most recent headlines say the active ingredient in the drug cuts tumor growth in common lung cancers in half and greatly reduces the ability of the cancer to spread.

Researchers at Harvard University tested marijuana's main ingredient, delta-tetrahydrocannabinol or THC, in both lab and mouse studies and say their experiments are the first to show THC inhibits the growth of cancer.

Researchers are not certain why THC inhibits tumor growth, but it could be that the substance activates molecules that arrest the cell cycle. THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

There is a long way to go in the study of THC. Yet "the beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," says Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.

Thought for the Day: Stopping cancer in its tracks

It might not be possible at this time to eradicate cancer altogether. But we may be able to stop cancer cells in their tracks through a process called senescence.

In senescence, cells don't divide. And when cells don't divide, they don't grow. In such a scenario then, cancer cells wouldn't divide and therefore couldn't grow.

Think about this:

According to lab tests on mice, triggering senescence in certain cells hampers the growth of some tumors.

Researchers at the University of Texas M.D. Anderson Cancer Center in Houston are the ones behind the scenes on this project -- the study appears online in
EMBO Reports, a publication of the European Molecular Biology Organization -- and all eyes are on the p53 gene.

The p53 gene lives within cells and works to nip cancer in the bud by springing to action in damaged cells that may be spinning themselves into a cancer frenzy.

Researchers say senescence ordered by the p53 gene is extremely important in suppressing tumor formation and is as important as apoptosis -- a type of programmed cell death. But in some cancers, senescence might not be enough to halt cancer, they found.

OK, so senescence is not a perfect approach to halting all cancers. But it seems to work for some -- so I say for now, let's take what we can get.

Thought for the Day: Cooking out cancer with pizza

Pizza just might have the power to fight cancer -- not the pizza loaded with cheese and pepperoni and tons of tempting toppings, the kind that may have your mouth watering at this very moment. But a version of pizza as we know it may fend off heart disease, obesity, and cancer.

The secret is in the crust -- the cooking of the crust, that is.

Think about this:

It seems baking pizza faster and at higher temperatures can release disease-fighting antioxidants. And it's this one small change to pizza preparation that has scientists at the University of Maryland claiming there is such a thing as a healthy pizza.

Scientists baked pizza at 500 degrees for six minutes and were able to increase antioxidant levels 100 percent. They used whole wheat dough, already high in antioxidants, and let it rise overnight before using their hotter, quicker cooking approach.

One researcher says this study is more a lab curiosity than anything else and might not really lead to a healthier pizza -- because it's unlikely pizza joints will change cooking methods to turn out healthier products.

If you are tempted to try this technique, be aware that the toxin acrylamide can be released if the pizza is baked too long. And don't forget to cut way back on those tasty toppers.

A study in mouthwash

A lab in Oklahoma is studying genes for combinations that predict breast cancer risk. A look into the 100 genes gathered from each woman -- via mouthwash -- allows researchers to categorize women with standard, moderate, or high risks of developing the disease.

The study begins with a lengthy questionnaire about medical history and leads to the collection of a DNA sample. Women simply rinse their mouths with a standard mouthwash and wait for results.

Geneticist Dr. Kara Casas says she hopes that regardless of results, women will choose a healthy lifestyle with a diet low in fat and alcohol consumption and with lots of exercise too. But those in the moderate and high-risk groupings will be advised to make other lifestyle changes to help decrease their chances of getting breast cancer. They may be asked to regulate estrogen levels, for example, and to report regularly for mammograms at an earlier age.

Casas says all women have some risk of developing breast cancer. But knowing what these risks are can help them better protect themselves -- which makes tests like this so important.

A total of 12,000 samples will collected for an FDA trial. For more information about this study in mouthwash, call 903-510-1173.

Lab mishap leads to shocking cancer discovery

Katherine Schaefer was investigating methods for treating the inflammation seen in Crohn's disease and ulcerative colitis when something terrible happened -- she noticed her carefully cultured cells were dead. And then something wonderful happened -- she realized she had stumbled upon a potential new method of attacking cancerous tumors that have become resistant to existing drugs.

Schaefer and her colleagues at the University of Rochester Medical Center in New York were testing a compound called a PPAR-gamma modulator -- a compound never considered a cancer drug, or a drug of any kind really -- when Schaefer made a calculation error and used a lot more of the compound than she should have. And her cells died.

Upon further study, Schaefer found the compound killed just about every possible epithelial tumor cell. These cells line organs such as the colon and also the skin. The compound, that works like taxane drugs but without eventual tumor resistance, also killed colon tumors in mice without making them sick.

The research team, whose findings are published in the journal International Cancer Research, plans more safety tests in mice. And eventually, if their outcomes are promising, they plan to design something they can patent as a new drug -- because they would love to see this disastrous lab experiment one day lead to treatment for cancers of the colon, esophagus, liver, and skin.

Uncertain future for drug used to shrink tumors

Canadian researcher Evangelos Michelakis, associate professor of medicine at the University of Alberta in Edmonton, has stumbled upon something quite remarkable -- a potentially new anti-cancer agent called dichloroacetate, or DCA.

DCA is nothing new -- it's long been used for treatment of rare metabolic disorders -- but using it to fight cancer puts an entirely new spin on the potential of this drug.

"This is one of the most exciting results I've ever had," Michelakis said. "But I can't be overenthusiastic until it works on a human."

Michelakis and his colleagues have successfully used DCA to shrink human lung, breast, and brain tumors in both lab rats and test tubes. And while this type of research may not ordinarily generate a lot of excitement, this specific study is creating a buzz because DCA has been safely used in humans for decades, without adverse side effects.

"One of the big concerns about drugs is that they can harm people but we already know this drug is safe," Michelakis says. "It doesn't even affect normal cells."

One of the fundamental premises of cancer biology is that mitochondria -- the energy producing units of cells -- are permanently damaged by cancer. What DCA does is revive the mitochondrial function, encouraging the death of cancer cells.

The overwhelming hope is that DCA will move right to human testing. But the overwhelming fear is that it will not -- because of economic reasons. There is no longer a patent on DCA so it is not owned by any one company. With little chance of one group making a large profit, there may be no incentive for pharmaceutical companies to invest in research.

Sadly, this drug -- that appears to work remarkably well -- may never benefit cancer patients. All because no one stands to make billions of dollars from it.

Researchers make unexpected breast cancer discovery

Canadian researchers have made an unexpected discovery in a molecule that appears to drastically boost the ability of standard drugs to kill breast cancer cells. Currently, the discovery has been confined to the lab -- but researchers hope the power of this molecule, the ANK peptide, can one day be used to counter drug resistance for many women with breast cancer.

Scientists from Queen's University say the ANK peptide, not a drug by itself, gives drugs like taxol and nocodazole more than triple the ability to kill breast cancer cells. One scientist says the process of enhancing drug effectiveness is much like adding flavor to coffee to make it taste better.

This is exciting news, but the results -- published Monday in the journal Cancer Research -- only apply to lab experiments at this point. Researchers must now proceed with testing the peptide-drug combination in lab mice. If successful, they will move on to human testing. The whole process could take years. But early results are so promising that application for a U.S. patent on the peptide has already been made.

According the medical experts, breast cancer patients can become resistant to some drugs depending on duration of treatment, dose of medication, and genetic makeup.

"This peptide would be able to give them another chance," said a researcher from this study. "For those who respond reasonably well, they will do even better; for those who don't respond to this drug treatment ... we greatly hope this will make the current drug more useful by extending its impact to a wider range of people, particularly those with a resistance problem."

If only bugs could cure cancer

I took my boys yesterday for a tour of the University of Florida's Department of Entomology and Nematology. Translation for these little boys -- ages five and three -- involves one simple word. Bugs. They love bugs, hunt for bugs, capture bugs, and reluctantly set them free because I coax them into allowing these itty bitty creatures to continue living with their "mommies and daddies." I have a soft spot for all living beings -- bugs included.

We learned some crazy facts about bugs yesterday -- insects is the proper term really. We learned there is one cockroach that can live for seven days without its head. We learned there are two types of Madagascar cockroaches living in a lab in the very same building we visited that if set free, would reproduce so quickly they would become a major pest problem in the state of Florida. And we learned that of all animals on this planet, most are insects. But not only did we learn some crazy facts, we -- well, Joey -- shared a crazy fact too.

Joey is five years old. He is the boy who remembers much of my breast cancer journey. He is the one who helped shave my head, the one who thought a banana would make my sick tummy feel better. He's the one who would blurt out to people we never knew very well, "My mommy is bald," the one who asked me just last night if the metal thing -- my port -- was still in my chest. When I told him it's gone, he jumped up and announced, "Yeah, it's gone!" Cancer is one of many vocabulary words housed in Joey's brain. And sometimes the word comes up unexpectedly, in strange contexts, in surprising ways. Like today.

Our bug tour guide told us that in Africa, mosquitoes transmit diseases that kill millions of people. But those with sickle cell anemia are immune to the deadly diseases due to their compromised red blood cells that somehow fend off disease. This fact prompted Joey to share with the guide, "Did you know when people have cancer, there are bugs that can kill the cancer?" Our guide listened to this crazy fact and said in a kid-friendly way, "No, I did not know that. Who told you that?" Joey told her, "I don't remember but someone told me."

I am not sure what prompted Joey to make this announcement. Perhaps he was trying to one-up the tour guide, to sound like an expert on one of his favorite subjects. Perhaps his imagination was in overdrive and he blurted out the best story he could offer. Perhaps he jumbled up a story he had heard on the topic of cancer. And perhaps he is just simply hopeful that one day, bugs will help cure cancer. And wouldn't that be nice -- a simple mosquito comes along, pierces the skin, and poof, cancer is gone.

My cancer journey would not be nearly as interesting, as enlightening, as tender if Joey was not along with me for the ride. He keeps me busy and keeps my spirits up. He keeps me grounded and keeps life simple. Best of all -- he keeps me laughing.

Zebrafish: efficient and effective in lab research

Phylonix Pharmaceuticals researchers have announced results that show zebrafish are an efficient and effective animal model for assessing human melanoma, colorectal and pancreatic cancer cells at various stages of tumorigenesis.

According to the researchers, human cancer cells were not rejected by zebrafish embryos, a major problem with other animal models and new zebrafish angiogenic vessels formed in and around human cancer cell masses, similar to the process of cancer progression in humans.

There is growing interest in using zebrafish and some of the advantages in using zebrafish is that they are small; provide an opportunity in short experimental time; there is a statistically significant number of animals per test; zebrafish require only a small amount of drug and they are inexpensive to maintain.

For more information about zebrafish research, visit Phylonix Zebrafish Assays for Drug Screening.

Senator calls home DNA tests modern day snake oil

Republican Senator Gordon Smith of Oregon calls home DNA kits for cancer and other diseases as nothing more than modern day snake oil and he believes consumers are being misled and exploited.

Smith, chairman of the Senate Special Committee on Aging, released a report from the Government Accountability Office on home DNA test products. He stated he is shocked to learn how little the federal government is doing to protect consumers in awareness and education regarding the uselessness of these products.

According to a Congressional report, home DNA tests or nutrigenetic tests, are not clinically valid and companies selling them are making unproven and ambiguous health-related predictions.

The Food and Drug Administration (FDA) and the Centers for Medicare and Medicaid Services said they were investigating the companies to determine is oversight was needed.

New development on tests to detect breast cancer

Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women, after lung cancer. Right now there are slightly over two million women living in the U.S. who have been treated for breast cancer.  Maritech is researching new and less expensive ways to detect breast cancer.

Matritech scientists, using a research mass spectrometer, discovered the existence of certain proteins in the blood of breast cancer patients that were generally not present in the blood of women without detectable breast malignancy. Matritech is developing test methods for NMP66 proteins in a proprietary laboratory procedure. Results of the company's testing indicate that NMP66 proteins found in the blood of women with breast cancer may enable physicians to more effectively manage women with or at a risk for breast cancer.

Continue reading New development on tests to detect breast cancer

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