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Posts with tag multiple

Canada says OK to cannabis spray for cancer pain

Health Canada has approved a medicated spray made from the ingredients of the cannabis plant. The medication, called Sativex, provides patients with advanced cancer a new option for pain management.

Sativex was approved in 2005 for use by patients with multiple sclerosis and has not caused any adverse side effects. Most pain-killing drugs, like Opioids, can't make this claim. They are still very good at what they do, though so for cancer pain, it's likely they will be used in conjunction with Sativex but at lower doses.

For those who may view drugs like Sativex as illicit substances -- because they are derived from cannabis -- one palliative medicine physician says the original substance has been modified and in its medicinal form is an appropriate and legitimate treatment.

Medical marijuana bill vetoed by cancer survivor Governor

Connecticut Governor M. Jodi Rell is a cancer survivor. And so she knows the pain and heartbreak associated with the disease. Still, she vetoed a bill that would have allowed people with serious illnesses to use marijuana for medicinal purposes. It's just too problematic and sends mixed messages to children, Rell said in a statement last Tuesday.

The decision was a struggle for the Republican Rell, who was diagnosed with breast cancer in 2004 and underwent a mastectomy just after taking office. Had she not vetoed the bill, those older than 18 with medical conditions such as cancer, multiple sclerosis, and AIDS would have been permitted to grow and use medical marijuana plants with written permission from a doctor and after registering with the state.

Twelve states allow patients to use medical marijuana despite federal laws forbidding it. Connecticut, for now, will not be joininig these states.

Rock musician Richard Bell dies of multiple myeloma

Keyboardist and songwriter Richard Bell, one-time member of Janis Joplin's band, died one June 15 of multiple myeloma in a Toronto hospital. He was 61.

Bell, who began playing with Joplin's Full Tilt Boogie Band in 1970, was diagnosed with cancer one year ago. He received intensive treatment and made a comeback, despite his poor prognosis. This past spring, however, his cancer returned.

Bell is also known for his musical work with artists such as Bob Dylan, Judy Collins, Joe Walsh, Paul Butterfield, The Cowboy Junkies, Bruce Cockburn, and Bonnie Raitt. His most recent gig was with the Toronto jazz and blue group Pork Bellies Futures.

He is survived by his mother, his sister, and his nieces and nephews.

Found: Four genes that spread breast cancer to lungs

A new study of mice implanted with human breast cancer cells shows the spread of the disease to the lungs -- a common metastasis site -- is caused by the abnormal activation of four specific genes working together.

The study, published in the journal Nature, indicates that shutting off the genes one by one can slow the growth and spread of this cancer. But turning off all four at one time almost completely stops the process. In mice anyway.

These genes are no strangers to researchers who have known for some time about their existence and functions. They just know more about them now.

The four genes work together at every step of the metastatic process to allow a breast tumor to develop blood vessels, let tumor cells enter the vessel walls and lungs, and permit them to pass out of the lung vessels and resume growth. New analysis shows that blocking these genes significantly reduces the tangle of blood vessels, making it harder for cancer cells to escape.

Researchers, who say the four genes are among 18 they associate with breast cancer metastasis, report that one implication of this study is clear: combined use of drug therapy may be more effective at inhibiting the activity of multiple gene targets.

Instant messaging for a cause

Here's an easy way to make a charitable difference -- send an instant message.

Students at 35 colleges and universities are doing it, and it's turned into a great way to create awareness and raise funds for nine nonprofit organizations.

The organizations -- American Red Cross, Boys and Girls Clubs of America, National AIDS Fund, National Multiple Sclerosis Society, ninemillion.org, Sierra Club, Stopglobalwarming.org, Susan G. Komen for the Cure, and U.S. Fund for UNICEF -- receive a portion of advertising revenue every time a student has a conversation using instant messaging (or i'm).

It's all part of a Microsoft-sponsored campus program, and students get to choose their recipient organization each time they send an instant message.

There is no cap on the amount each group can receive, and Microsoft will make a guaranteed donation of at least $100,000 to each organization during the first year of the program.

Visit www.imforacause.com for more information.

Prostate cancer drug trial halted for causing leukemia

A clinical study involving 1,000 prostate cancer patients was stopped this week by Southwest Oncology Group in Michigan due to concerns the treatment may have caused leukemia in three of the participants.

The men in the study received the chemotherapy drug mitoxantrone, thought to possibly improve survival rates for those with poor prognoses following prostate surgery. But before results could be measured, leukemia struck and researchers halted the study, declaring the leukemia findings "an unacceptable risk to patients."

While the assumption is that the drug caused the leukemia -- a disease commonly associated with children and the elderly -- it's still unproved at this point.

Mitoxantrone is not a worthless drug, say some experts. Since its release a decade ago, it has been used to decrease bone pain for men with advanced prostate cancer and to treat multiple sclerosis and, ironically, adult leukemia.

Viagra might help the immune system detect cancer cells

The drug sildenafil, better known as Viagra has been shown in mice to support the immune system's response to cancer cells. Mice with colon and breast tumors showed that the tumor size decreased two and threefold when treated with sildenafil compared with the mice that did not receive the drug. The researchers also believe that they have evidence that sildenafil is effective on the immune system because in mice engineered to lack an immune system the tumors were unaffected. Tissue samples taken from head and neck cancer and multiple myeloma patients showed similar results.

Viagra is a class of drugs used to treat impotence. It is known to stimulate nitric oxide which hinder the effects of a specialized cell that can divert the immune system away from the tumor. The researchers are trying to figure out how cancer cells can avoid detection by the immune system. T-cells that mount the attack on cancer cells are manipulated by the cancer cells and prevent them from being seen by the immune system. Viagra can unmask the cancer cells and let the immune system recognize and attack them.

Cancer by the Numbers: Cervical Cancer

Cervical cancer was once the most common cancer in women. But between 1955 and 1992, the number of cervical cancer deaths dropped by 74 percent -- thanks to increased use of the Pap test, a screening tool that can find changes in the cervix before cancer develops and can also detect cancer in its most curable stage. The Pap test is still widely used. And the cervical cancer death rate continues to drop four percent every year.

In 2006, about 9,700 new cases of invasive cervical cancer will be diagnosed in the United States. About 3,700 women will die from the disease. Non-invasive cervical cancer is believed to be four times more common than the invasive form of the disease. Nearly all of these cases can be cured.

Cervical cancer typically occurs in women between the ages of 35 and 55 and rarely in women under the age of 20. It affects mostly Hispanic women, and African-American women develop the disease 50 percent more often than non-Hispanic white women. Women most as risk for cervical cancer are smokers, those with HIV or chlamydia infections, those with diets low in fruit and vegetable consumption, those who between 1940 and 1971 took the hormonal drug DES, and those who have taken oral contraceptives for extended periods of time. Women who have had multiple pregnancies, have a family history of the disease, and have a low socio-economic status are also at risk. Those most at risk, however, are women with human papilloma virus.

Human papilloma virus (HPV) is the most common risk factor for cervical cancer, and some experts believe a woman must have HPV to contract cervical cancer. There are 100 different types of HPV, 13 of which are likely to cause cervical cancer through sexual contact. There are usually no symptoms of HPV, but possible signs of cervical cancer can include vaginal bleeding, unusual discharge, pelvic pain, and pain during sexual intercourse.

There are two ways to stop cervical cancer. First, women can protect themselves against HPV. Protection comes in the form of delaying sexual activity, limiting the amount of sexual partners and their partners, using condoms (thought to be 70 percent effective) and receiving the cervical cancer vaccine, recommended for use in females ages 11-26. The vaccine is most effective for women who have never been sexually active. Second, women can receive regular Pap tests in order to catch pre-cancers. Pap tests are recommended for women three years after their first sexual encounter and before the age of 21 -- and then every year after that.

An abnormal Pap test typically prompts a colposcopy -- a technique that uses a scope to examine the cervix. Diagnosis usually stems from a combination of other scoping methods, pelvic exams, imaging tests, and biopsies used to confirm the presence of cancer and to stage the disease. Stages range from 0-4.

For non-invasive cervical cancer, surgery -- ranging from removal of the cancerous tissue to hysterectomy -- may be the only treatment necessary. For invasive forms of the cancer, surgery is often followed by radiation and chemotherapy. Women interested in preserving their fertility should discuss options with their physicians.

The state of cervical cancer has come a long way over the years. And this year, two critical developments emerged. In June 2006, the FDA approved the first drug for late-stage cervical cancer. The drug, Hycamtin, is recommended for use in combination with chemotherapy. Also is June, the cervical cancer vaccine, Gardasil, was released. Both developments are monumental -- and both will undoubtedly help decrease the already-dropping cervical cancer death rate.

For more information about cervical cancer, visit the following sites:

American Cancer Society
Mayo Clinic
Medline Plus
National Women's Health Information Center

Treatment combination effective against multiple myeloma

The treatment combination of Revlimid (lenalidomide), Oncovin (vincristine), Doxil (pegylated doxorubicin) and dexamethasone appears to be highly effective in multiple myeloma that has recurred or progressed following prior therapies.

According to an article published in the Annals of Oncology, researchers from the Cleveland Clinic conducted a clinical trial to evaluate this combination of drugs. The trial included 62 patients, 75 percent of the patients achieved an anticancer response and 29 percent of patients achieved a complete or near complete disappearance of detectable cancer.

The researchers note that determining treatment choices for those patients who recur after initial therapy is more challenging than treating patients that have not received prior therapy. Multiple myeloma is usually treated with chemotherapy -- however -- new treatments are evolving that are better tolerated, especially in older patients who cannot handle aggressive chemotherapy. The researchers continue to evaluate strategies in order to offer patients individualized treatment options.

Clinical trial using measles to attack cancer cells

The Mayo Clinic Cancer Center has opened a new clinical study today using a vaccine strain of the measles virus to attack recurrent glioblastoma multiforme (GBM). The Mayo Clinic's research has grown from the most basic laboratory science to the sophisticated therapy being tested today on several tumor types, including GBM, recurrent ovarian cancer and multiple myeloma.

The study is designed to test the safety of the virus for the treatment of gliomas and enable monitoring of anti-tumor activity. Eligible candidates for the therapy will have GBM that has progressed after surgery and radiation therapy. They also must be immune to measles, either having had the disease or been vaccinated against it.

Many cancer cells, including glioblastoma cells, overexpress a specific protein which allows tumor cells to avoid destruction by the immune system. Strains of the measles virus seek out this protein and enter the tumor. When it enters the virus begins to spread infecting nearby tumor cells which increases cancer cell death.

Back in the1970's it was noted that measles infections could cause regression of cancer tumors in children. Nothing was done about studying this phenomenon until late in the 1990's when the Mayo Clinic Cancer Center's Molecular Medicine Program began looking into it. The researchers are now also looking at ways to use the measles virus to combat breast and pancreatic cancer, they already have plans to open up another clinic study this fall to test the effectiveness of a version of the measles virus on multiple myeloma.

Mariska's dad Mickey Hargitay dies of multiple myeloma

Actress Mariska Hargitay lost her father on Thursday to multiple myeloma. Mickey Hargitay, the 1955 Mr. Universe, Mr. America, Mr. Olympia, and one-time husband of late sex symbol Jayne Mansfield died at the age of 80 at Cedars-Sinai Medical Center in Los Angeles.

Born Miklos Hargitay in Hungary, Mickey emigrated to the United States after World War II. Here he entered the world of bodybuilding and then landed a role in Mae West's Las Vegas Revue. Mansfield, who saw the show in 1956, married Hargitay in 1958 -- and the two later had daughter Mariska and two other children. Mansfield and Hargitay divorced in 1964 -- and Mansfield died in a car crash in 1967.

Family members shared in a statement to the media, "words cannot express how saddened we are by the loss of Mickey. At the same time, we are so grateful for who he was and is to all of us, and for the love he gave us in our lives. He will continue to be our source of inspiration and strength."

Hargitay, also know for a few Hercules-style movies, is survived by his wife of 38 years, Ellen, a daughter, a stepdaughter, two sons, a brother, a sister, 10 grandchildren and three great-grandchildren.

Cancer Etiquette

I found a book called Cancer Etiquette. The book was written by a woman who is a survivor of multiple myeloma and breast cancer. In this manners guide to cancer you can find advice on what to say to a cancer patient and what not to say. For example, only say "you look terrific" if the person really does look terrific.

The author Rosanne Kalick also tells us that we should be more specific when offering help to a cancer patient. Don't just say that you're there for them. Offer to do something tangible like cook a meal or baby-sit the kids. Rosanne talks about the distressing comments sometimes said to cancer patients and offers helpful advice on what should be said instead.

This book would be very helpful to caregivers, friends or family members of loved ones dealing with a life threatening illness.

I wrote another post a few days ago called Things not to say to a cancer patient. Well, here are some great things that were said to me when I was going through my cancer journey. These things helped tremendously!

  • I will drive you to your chemo treatment.
  • Here is some dinner I made for you and your husband.
  • I would love to go wig shopping with you.
  • Call me any time and I'll be here to talk.
  • You still look beautiful to me bald.
  • Here are some xanax!
  • Can I give you a foot rub?
  • Sure, I can take your nipple off and move it to where it belongs (plastic surgeon).
  • I'll drive 2 hours to your house and go with you and stay while you get your breast biopsy and wait for the results.
  • Hang in there.
  • I love you.

Cancer is one of many occupational hazards for firefighters

Firefighters pull off heroic maneuvers all the time. Heat and smoke and fire are their constant companions. Emergency scenarios keep them perpetually challenged. Risking their lives is a top job responsibility. I can't imagine taking on this line of work, yet I am amazed by those who do -- for their eagerness to save lives while compromising their own. And to read today that cancer is another occupational hazard for firefighters makes me appreciate them even more.

In Edmonton, a firefighter who was praised as a hero for saving the life of a rookie firefighter in 2003 died on Saturday of job-related cancer at the age of 47 -- just two years after doctors diagnosed him with a terminal form of multiple myeloma. Clarke Stevens was expected to live for five years.

Ken Block, president of the Edmonton firefighters union said Stevens' death is a reminder of the risks these heroes take. Block says firefighters are between two and four times more likely to develop certain cancers, and Stevens is the fifth Edmonton firefighter to die of cancer since 2004.

It takes a special person to make saving others' lives a priority. To risk death in so many ways -- for the benefit of strangers -- must be the true definition of selflessness. And thank goodness for these selfless individuals who help keep the rest of us safe.

Working mothers healthier than stay-at-home mothers

Before I even get started, here is a sampling of the news headlines that are appearing in relation to a study indicating mothers who work outside the home are in better health than stay-at-home mothers. Working mothers less likely to become obese -- Working moms healthier than full-time homemakers -- Mothers who work enjoy better health -- Working Moms -- Healthier and thinner.

According to researchers who analyzed data from a study that tracked the health of women born in 1946 -- women who were employed outside the home were less likely than stay-at-home mothers and single mothers to report poor health or to be obese in middle age. Obesity is a known lifestyle factor contributing to a greater risk for a number of cancers. However, Dr Anne McMunn, of the University College in London, takes obesity into a debatable realm when she states that it has been known for some time that women who combine employment with motherhood and partnership have better health.

Continue reading Working mothers healthier than stay-at-home mothers

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